BDBM50222491 CHEMBL249928::N-(2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-5-yloxy)ethyl)-2-hydroxy-N-methylacetamide

SMILES CN(CCOc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)CO

InChI Key InChIKey=XNMHWKJRXNZELF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50222491   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222491(CHEMBL249928 | N-(2-(4-(3-chloro-4-(pyridin-2-ylme...)
Affinity DataIC50:  43nMAssay Description:Inhibition of Erb2 autophosphorylation by cellular clone 24 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222491(CHEMBL249928 | N-(2-(4-(3-chloro-4-(pyridin-2-ylme...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of KdrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222491(CHEMBL249928 | N-(2-(4-(3-chloro-4-(pyridin-2-ylme...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ErbB2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222491(CHEMBL249928 | N-(2-(4-(3-chloro-4-(pyridin-2-ylme...)
Affinity DataIC50:  35nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222491(CHEMBL249928 | N-(2-(4-(3-chloro-4-(pyridin-2-ylme...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed