BDBM50222492 (S)-N-(1-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-5-yloxy)propan-2-yl)-2-hydroxy-N-methylacetamide::CHEMBL403785

SMILES C[C@@H](COc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)N(C)C(=O)CO

InChI Key InChIKey=HXMKNGQXLJHQDQ-KRWDZBQOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50222492   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222492((S)-N-(1-(4-(3-chloro-4-(pyridin-2-ylmethoxy)pheny...)
Affinity DataIC50:  131nMAssay Description:Inhibition of Erb2 autophosphorylation by cellular clone 24 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222492((S)-N-(1-(4-(3-chloro-4-(pyridin-2-ylmethoxy)pheny...)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50222492((S)-N-(1-(4-(3-chloro-4-(pyridin-2-ylmethoxy)pheny...)
Affinity DataIC50:  19nMAssay Description:Inhibition of ErbB2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed