BDBM50223316 1-(1-benzyl-7-chloro-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(isoquinolin-5-yl)urea::CHEMBL250762

SMILES Clc1ccc2CCC(NC(=O)Nc3cccc4cnccc34)C(Cc3ccccc3)c2c1

InChI Key InChIKey=NFFVSJUMRUCIOC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50223316   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223316(1-(1-benzyl-7-chloro-1,2,3,4-tetrahydronaphthalen-...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223316(1-(1-benzyl-7-chloro-1,2,3,4-tetrahydronaphthalen-...)
Affinity DataIC50: 86nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed