BDBM50223332 1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-(pyridin-3-yl)propyl)urea::CHEMBL250169

SMILES COc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1cccnc1

InChI Key InChIKey=TYNWYOMSZOLTRN-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50223332   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223332(1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-(pyr...)
Affinity DataIC50: 184nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223332(1-(isoquinolin-5-yl)-3-(2-(4-methoxyphenyl)-3-(pyr...)
Affinity DataKi:  578nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed