BDBM50223339 1-(2-(4-fluorophenyl)-3-phenylpropyl)-3-(isoquinolin-5-yl)urea::CHEMBL250370

SMILES Fc1ccc(cc1)C(CNC(=O)Nc1cccc2cnccc12)Cc1ccccc1

InChI Key InChIKey=KGKYSZLDVDJKPT-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50223339   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223339(1-(2-(4-fluorophenyl)-3-phenylpropyl)-3-(isoquinol...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50223339(1-(2-(4-fluorophenyl)-3-phenylpropyl)-3-(isoquinol...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed