BDBM50224399 8-(4-methylphenyl)thiazolo[4'',5'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,7(1H,8H)-dione::CHEMBL392164

SMILES Cc1ccc(cc1)-n1cnc2c(sc3[nH]cc4sc(=O)nc4c23)c1=O

InChI Key InChIKey=OSBJTQPBAMABGG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50224399   

TargetMetabotropic glutamate receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224399(8-(4-methylphenyl)thiazolo[4'',5'':4',5']pyrido[3'...)
Affinity DataIC50: 446nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224399(8-(4-methylphenyl)thiazolo[4'',5'':4',5']pyrido[3'...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed