BDBM50224423 CHEMBL239630::N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-2,3-dihydro-1Himidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide

SMILES Fc1ccccc1[C@@H]1CC[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)NC1

InChI Key InChIKey=LLKYZEVAQYETNP-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50224423   

TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224423(N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224423(N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224423(N-[(3R,6S)-6-(2-fluorophenyl)-2-oxoazepan-3-yl]-4-...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed