BDBM50224732 4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxyquinazoline::CHEMBL236487

SMILES COc1cc2ncnc(N3CCN(Cc4ccc(F)cc4)CC3)c2cc1OC

InChI Key InChIKey=ZJOTWAJZHISRRW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50224732   

TargetAcetylcholinesterase(Human)
Indian Institute of Technology-Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50224732(4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxy...)
Affinity DataIC50: 932nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Indian Institute of Technology-Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50224732(4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxy...)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of human BACE-1 measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCholinesterase(Human)
Indian Institute of Technology-Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50224732(4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50224732(4-(4-(4-fluorobenzyl)piperazin-1-yl)-6,7-dimethoxy...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed