BDBM50226446 2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one::CHEMBL237888

SMILES Cn1c(N)nc(CCc2ccccc2)cc1=O

InChI Key InChIKey=MALAKURYZJFBLT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50226446   

TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50: 1.71E+5nMAssay Description:Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of human recombinant BACE1 using biotin-XSEVNLDAEFRHDSGC-Eu as substrate after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226446(2-amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one | ...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed