BDBM50226633 CHEMBL393584::N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-6-methyl-3-pyridinyl]-3-methylbutyl)-3-(dimethylamino)propionamide

SMILES CC(C)C[C@@H](NC(=O)CCN(C)C)c1ccc(C)nc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1Cl

InChI Key InChIKey=GLNBATBKCBLDAT-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50226633   

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human MC4R expressed in HEK293 cells assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC5R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC3R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50226633(N-((1R)-[2-{4-[2R-methyl-3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  6.40E+3nMAssay Description:Displacement of [125I]NDPMSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed