BDBM50227986 (6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::(6S,7S)-N-hydroxy-6-(3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL252246

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(C1)c1ccccc1

InChI Key InChIKey=XKPUKZQRNSFQLM-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50227986   

LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 97nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 323nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 323nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 358nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 359nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 960nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 998nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 998nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed