BDBM50230362 CHEMBL4070806

SMILES CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C

InChI Key InChIKey=QBVIRPJBDIZKBC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50230362   

TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of PHGDH (unknown origin) preincubated for 30 mins followed by substrate addition and measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of PHGDH (unknown origin) expressed in Escherichia coli BL21 using 3-phosphoglycerate as substrate preincubated for 4 hrs followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 3.30E+4nMAssay Description:Non-competitive inhibition of His6-tagged full length PHGDH (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in NADH f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of PHGDH (unknown origin) expressed in Escherichia coli BL21 using 3 -phosphoglycerate as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of His6-tagged PHGDH (unknown origin) expressed in Escherichia coli BL21 assessed as effect on NADH fluorescence pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Innovation Research Institute of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50230362(CHEMBL4070806)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of His6-tagged pET28a human PHGDH expressed in Escherichia coli using 3-phosphoglycerate as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed