BDBM50231596 CHEMBL4074150

SMILES CCCn1c(Oc2ccc(F)c(F)c2)nc2nc([nH]c2c1=O)C1CCCC1

InChI Key InChIKey=UUGKUAPXWUSTOD-UHFFFAOYSA-N

Data  7 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50231596   

TargetAdenosine receptor A1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human adenosine A1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi:  13nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Isf College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi:  23nMAssay Description:Binding affinity to human adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]HEMADO from human adenosine A3 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231596(CHEMBL4074150)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2019
Entry Details Article
PubMed