BDBM50231921 1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amine::CHEMBL438888

SMILES CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12

InChI Key InChIKey=AREQCBAQXYOCPQ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50231921   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  12nMAssay Description:Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed