BDBM50234162 (6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-7-(4-fluorophenyl)tetrahydro-1H-pyrrolizin-3(2H)-one::(6R,7S,7aS)-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluorophenyl)hexahydro-3H-pyrrolizin-3-one::CHEMBL272649

SMILES C[C@@H](O[C@H]1CN2[C@@H](CCC2=O)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=SUITYIWBXSZXIQ-MJRZITLZSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50234162   

TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human PXR inductionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50234162((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed