BDBM50235630 CHEMBL4093096

SMILES CN(C)[C@H]1CC(C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(C)(=O)=O)C1CCc2cccc(F)c12

InChI Key InChIKey=ZPYZUHUGHFFSDX-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50235630   

TargetPolycomb protein EED(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50235630(CHEMBL4093096)
Affinity DataKi:  0.300nMAssay Description:Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50235630(CHEMBL4093096)
Affinity DataIC50: 44nMAssay Description:Inhibition of EED in human OCILY19 cells assessed as reduction in H3K27 trymethylation measured after 6 days by alphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2019
Entry Details Article
PubMed
TargetPolycomb protein EED(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50235630(CHEMBL4093096)
Affinity DataIC50: 57nMAssay Description:Inhibition of EED in human G401 cells assessed as reduction in H3K27 trymethylation measured after 6 days by alphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2019
Entry Details Article
PubMed