BDBM50235698 CHEMBL4069070

SMILES COc1ccc(OC)c(Sc2cccc3[nH]c4nc(N)nc(N)c4c23)c1

InChI Key InChIKey=TXHGXJGNQUMSBD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50235698   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation in human A431 cells preincubated for 60 mins followed by EGF induction measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells preincubated for 60 mins followed by VEGF induction measured after 10 mins by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235698(CHEMBL4069070)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of PDGF-BB-induced PDGFR-beta phosphorylation in human SF-539 cells preincubated for 60 mins followed by PDGF-BB induction measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed