BDBM50236535 CHEMBL1231132

SMILES CN(C)C(=O)c1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1

InChI Key InChIKey=DTDZLJHKVNTQGZ-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50236535   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant full-length human PDK1 (1 to 436 residues) expressed in baculovirus infected Sf9 insect cells using PDHA1 as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 41nMAssay Description:Inhibition of PDHK1 in human PC3 cells assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2019
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant full length human PDK2 (1 to 407 residues) expressed in baculovirus infected Sf9 cells using PDHA1 as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 80nMAssay Description:Inhibition of E2-activated human PDHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 80nMAssay Description:Inhibition of E2-activated human PDHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataEC50:  80nMAssay Description:Inhibition of PDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 121nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human full length PDK3 (1 to 406 residues) expressed in baculovirus infected Sf9 cells using PDHA1 as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataKd:  148nMAssay Description:Binding affinity to PDK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 540nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full length human PDK4 (1 to 411 residues ) expressed in baculovirus infected Sf9 cells using PDHA1 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Chongqing Medical and Pharmaceutical College

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to PDK1 (unknown origin) assessed as dissociation constant in presence of 5-((4-chlorophenyl)sulfonamido)-N-(2-hydroxyethyl)-2,4-dim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50236535(CHEMBL1231132)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed