BDBM50236785 CHEMBL4090355

SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC)nc(nc12)C#Cc1ccc(Cl)s1

InChI Key InChIKey=MTSSGMWKEDEGAV-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50236785   

TargetTransmembrane domain-containing protein TMIGD3(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from human A3AR expressed in HEK293T cells pre-incubated for 10 mins be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAdenosine receptor A3(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi:  1.17E+3nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse A3AR expressed in HEK293T cells pre-incubated for 10 mins be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAdenosine receptor A1(Mouse)
National Institute of Diabetes and Digestive and Kidney Disease

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi:  4.17E+3nMAssay Description:Displacement of [125I]AB-MECA from recombinant mouse A1AR expressed in HEK293 cells assessed as inhibitory constant by radio ligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi:  5.00E+3nMAssay Description:Displacement of [3H]Rauwolscine from human adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Rauwolscine from human adrenergic alpha2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Prazosin from human adrenergic alpha1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: <1.00E+4nMAssay Description:Inhibition of [3H]mazindol binding to recombinant human SERT expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Prazosin from human adrenergic alpha1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: <1.00E+4nMAssay Description:Inhibition of [125I]RTI-55 binding to recombinant human SERT expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50236785(CHEMBL4090355)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Prazosin from human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed