BDBM50236856 CHEMBL272198::N-cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide::N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide

SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)NC3CC3)c2cc1OC

InChI Key InChIKey=ZATGFXTWDKIEKC-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50236856   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  118nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  330nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of human VEGFR2 after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  466nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  396nMAssay Description:Inhibition of FGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  27nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50236856(CHEMBL272198 | N-cyclopropyl-6-(6,7-dimethoxyquino...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed