BDBM50237428 CHEMBL4093921

SMILES Cc1nc2ccc(cc2n1Cc1ccccc1)-c1ccc(CN2CCC[C@@H]2CO)cc1

InChI Key InChIKey=MDUQMHDMUKHVKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50237428   

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237428BDBM50237428(CHEMBL4093921)
Affinity DataIC50: 250nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50237428BDBM50237428(CHEMBL4093921)
Affinity DataIC50: 440nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed