BDBM502380 N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3- a]quinoxaline- 4-ylamino)- butyl]-3- methyl- butyramide::US11028090, Example 285

SMILES COc1ccc2c(c1)nc(NCCCCNC(=O)CC(C)C)c1nnc(C)n21

InChI Key InChIKey=NAPOLFVZKFHOBG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 502380   

TargetBromodomain-containing protein 3(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human BRD3 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  5.60nMAssay Description:Binding affinity to human BRD2 assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  6.70nMAssay Description:Binding affinity to human BRD4 BD1 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  14nMAssay Description:Binding affinity to human BRDT assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human BRD4 BD2 (44 to 460 residues) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human BRD4 BD1 (44 to 460 residues) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 17nMAssay Description:The following experiment was performed to evaluate the ability of [1,2,4]triazolo[4,3-a]quinoxaline derivative of the present invention to inhibit th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human BRD3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 144nMAssay Description:Inhibition of human BRDTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataIC50: 163nMAssay Description:Inhibition of human BRD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM502380(N-[4-(7- methoxy-1- methyl- [1,2,4]tri- azolo[4,3-...)
Affinity DataKd:  293nMAssay Description:Binding affinity to human BRD4 BD2 expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed