BDBM50238920 CHEMBL4093740

SMILES Cc1cn(CCCNc2ccccc2-c2ccc(F)cc2)cn1

InChI Key InChIKey=GKLQJZRXGKCXRX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50238920   

TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50238920(CHEMBL4093740)
Affinity DataIC50: 118nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50238920(CHEMBL4093740)
Affinity DataIC50: 118nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50238920(CHEMBL4093740)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of human N-terminal His6-tagged QC expressed in Escherichia coli BL21(DE3) using H-gln-gln-H as substrate in presence of NADH/H+ after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed