BDBM50239049 CHEMBL4086782

SMILES CCS(=O)(=O)c1ccc(Oc2cc3cc([nH]c3cc2C2CCC(=O)N2C)-c2ccc(cn2)C(F)(F)F)cc1

InChI Key InChIKey=NJMQGAPDEDUCFJ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239049   

TargetHexokinase-4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  1.40nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH couple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  1.70nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HILIC LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  2nMAssay Description:Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 2.5 mM glucose by G6PDH coupl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetHexokinase-4(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50239049(CHEMBL4086782)
Affinity DataEC50:  174nMAssay Description:Activation of glucokinase in primary rat hepatocytes assessed as increase in D-2-deoxyglucose-6-phosphate level in presence of D-2-deoxyglucose by HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed