BDBM50239303 CHEMBL4060577

SMILES COc1ccc(Nc2nc(nc3ccccc23)-c2ccncc2)cc1C(F)(F)F

InChI Key InChIKey=TWQHWJBUHDBUTM-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239303   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50239303(CHEMBL4060577)Copy SMILESCopy InChI

Affinity DataIC50: 146nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins follo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/20/2019
Entry Details Article
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TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50239303(CHEMBL4060577)Copy SMILESCopy InChI

Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of ABCB1 in human A2780adr cells assessed as reduction in calcein AM levels preincubated for 30 mins followed by calcein AM addition measu...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/20/2019
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL