BDBM50239320 CHEMBL4088963

SMILES Cc1cc(Nc2ccc(O)c(c2)[N+]([O-])=O)nc(n1)-c1ccccc1

InChI Key InChIKey=DPMCPGABBOYWTR-UHFFFAOYSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239320   

LigandPNGBDBM50239320(CHEMBL4088963)
Affinity DataEC50:  22nMAssay Description:Inhibition of human GFP-fused ABCG2 expressed in MDCK2 cells assessed as potentiation of mitoxantrone induced cytotoxicity by measuring cell viabilit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
LigandPNGBDBM50239320(CHEMBL4088963)
Affinity DataEC50:  62nMAssay Description:Inhibition of human GFP-fused ABCG2 expressed in MDCK2 cells assessed as potentiation of SN-38 induced cytotoxicity by measuring cell viability after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
LigandPNGBDBM50239320(CHEMBL4088963)
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
LigandPNGBDBM50239320(CHEMBL4088963)
Affinity DataEC50:  1.80E+3nMAssay Description:Activation of ABCG2 (unknown origin) ATPase activity expressed in baculovirus infected high five cell membranes by ascorbic acid/ammonia molybdate re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50239320(CHEMBL4088963)
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of ABCC1 in human H69AR cells assessed as reduction in calcein AM levels preincubated for 30 mins followed by calcein AM addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed