BDBM50239510 CHEMBL4064661::US10329302, Example 32::US10793579, Example 32::US11702424, Example 32

SMILES CC(C)Oc1cc2c(OC[C@H]3CCC(=O)N3)nccc2cc1C(N)=O

InChI Key InChIKey=YLJNGHKLWZPDSX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239510   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM50239510(CHEMBL4064661 | US10329302, Example 32 | US1079357...)
Affinity DataIC50: 840nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM50239510(CHEMBL4064661 | US10329302, Example 32 | US1079357...)
Affinity DataIC50: 840nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM50239510(CHEMBL4064661 | US10329302, Example 32 | US1079357...)
Affinity DataIC50: 840nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM50239510(CHEMBL4064661 | US10329302, Example 32 | US1079357...)
Affinity DataIC50: 840nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent