BDBM50239941 (S)-1-(4-(1-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hydroxyethyl)piperidin-1-yl)-3-(3,4,5-trifluorophenyl)prop-2-en-1-one::CHEMBL254355

SMILES OC[C@H](C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)N1CCC(CC1)c1c[nH]c2ccccc12

InChI Key InChIKey=KXZARDUIYCLEFF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239941   

TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50239941((S)-1-(4-(1-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hy...)
Affinity DataIC50: 2.40nMAssay Description:Binding affinity at human CCR2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50239941((S)-1-(4-(1-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hy...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at CCR2 receptor expressed in THP1 cells assessed as MCP-1-induced calcium flux by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50239941((S)-1-(4-(1-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hy...)
Affinity DataIC50: 4nMAssay Description:Binding affinity at human CCR2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50239941((S)-1-(4-(1-(4-(1H-indol-3-yl)piperidin-1-yl)-2-hy...)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [125I]MCP1 from human CCR2B receptor expressed in HEK293-EBNA cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed