BDBM50240516 CHEMBL4094558

SMILES [H][C@@]12CCCCN1C(=O)C(=O)[C@]1(O)O[C@@]([H])([C@H](C[C@H]1C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CCCC(=O)NCCc1ccccn1)C(=O)C[C@H](O)[C@@H](C)[C@H](OC2=O)C(\C)=C\[C@@H]1CC[C@@H](O)[C@@H](C1)OC)OC

InChI Key InChIKey=GHSIYHYXMCOTAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50240516   

TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Amplyx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240516(CHEMBL4094558)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human FKBP12 measured after 30 mins by fluorescein labelled SLF tracer based fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Amplyx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240516(CHEMBL4094558)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged FKBP12 expressed in Escherichia coli assessed as inhibition of FK506 mediated FKBP12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed