BDBM50240573 CHEMBL4077859

SMILES COc1cc(OC)c(F)c(COc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2)c1F

InChI Key InChIKey=FPLYXYDSEPGNHS-UHFFFAOYSA-N

Data  14 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50240573   

TargetFibroblast growth factor receptor 4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FGFR4 cytoplasmic domain (781 to 133 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

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Date in BDB:
10/4/2019
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TargetFibroblast growth factor receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant human His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus expression system using tyr 04 as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

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Date in BDB:
10/4/2019
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TargetVascular endothelial growth factor receptor 2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VEGFR2 using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatogr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
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TargetTyrosine-protein kinase ITK/TSK(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ITK using myelin basic protein as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
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TargetTyrosine-protein kinase JAK3(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
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TargetEpidermal growth factor receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograp...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetTyrosine-protein kinase BTK(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograph...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetTyrosine-protein kinase Tec(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograph...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetCytochrome P450 3A4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate pretreated for 10 mins followed by substrate addition measured after 10 m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetCytochrome P450 2C19(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate pretreated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

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Date in BDB:
10/4/2019
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TargetCytochrome P450 2C9(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate pretreated for 10 mins followed by substrate addition measured after 10 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetCytochrome P450 2D6(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate pretreated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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TargetCytochrome P450 1A2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL

LigandBDBM50240573(CHEMBL4077859)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate pretreated for 10 mins followed by substrate addition measured after 10 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/4/2019
Entry Details Article
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