BDBM50240575 CHEMBL4089245

SMILES COc1cc(OC)c(F)c(COc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2)c1F

InChI Key InChIKey=FSAPXEJFAWOTKO-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50240575   

TargetFibroblast growth factor receptor 4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FGFR4 cytoplasmic domain (781 to 133 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate pretreated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate pretreated for 10 mins followed by substrate addition measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate pretreated for 10 mins followed by substrate addition measured after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of recombinant human His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus expression system using tyr 04 as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VEGFR2 using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatogr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ITK using myelin basic protein as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FMS using poly[Glu:Tyr] (4:1) as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatograph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate measured after 120 mins in presence of [gamma33P]ATP by P81 ion exchange chromatographic m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate pretreated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240575(CHEMBL4089245)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate pretreated for 10 mins followed by substrate addition measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed