BDBM50241526 CHEMBL4095018

SMILES COc1ccc(CN(CC(=O)N2CCC(CN)CC2)c2ccc(cc2)C#N)cc1F

InChI Key InChIKey=XDSLEWVHSUVCPM-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50241526   

TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241526(CHEMBL4095018)
Affinity DataKd:  58nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241526(CHEMBL4095018)
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal truncated human LSD1 (151 to 852 residues) expressed in Escherichia coli after 30 mins using histone H3(1-21)K4(Me1) biotin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241526(CHEMBL4095018)
Affinity DataEC50:  4.10E+3nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD86 expression after 48 hrs by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241526(CHEMBL4095018)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human hERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed