BDBM50241539 CHEMBL4084845

SMILES Cc1ccc(cc1)-c1ncc(OC[C@H]2CCNC2)cc1-c1ccc(cc1)C#N

InChI Key InChIKey=IQVDLEXWAPYWDT-UHFFFAOYSA-N

Data  3 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50241539   

TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241539(CHEMBL4084845)
Affinity DataKd:  9nMAssay Description:Binding affinity to LSD1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241539(CHEMBL4084845)
Affinity DataIC50: 37nMAssay Description:Inhibition of N-terminal truncated human LSD1 (151 to 852 residues) expressed in Escherichia coli after 30 mins using histone H3(1-21)K4(Me1) biotin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241539(CHEMBL4084845)
Affinity DataEC50:  300nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD86 expression after 48 hrs by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241539(CHEMBL4084845)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50241539(CHEMBL4084845)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human hERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed