BDBM50242057 CHEMBL4067401

SMILES CCCn1c(=O)n(CC)c2nc([nH]c2c1=O)-c1cnn(CC#Cc2cccc(OC(F)(F)F)c2)c1

InChI Key InChIKey=GIQNDKZFMBWVIF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50242057   

TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242057(CHEMBL4067401)
Affinity DataKi:  8nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242057(CHEMBL4067401)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242057(CHEMBL4067401)
Affinity DataIC50: 107nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242057(CHEMBL4067401)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed