BDBM50242137 CHEMBL4070149

SMILES Cc1cc(C)nc(SCC(=O)Nc2cccc(COc3ccc(NC(=O)c4cccs4)cc3)c2)n1

InChI Key InChIKey=HUKQVZNTLUXOBR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50242137   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50242137(CHEMBL4070149)
Affinity DataIC50: 42nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50242137(CHEMBL4070149)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50242137(CHEMBL4070149)
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50242137(CHEMBL4070149)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50242137(CHEMBL4070149)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed