BDBM50243109 5-(2-m-tolylethynyl)pyrimidine::5-(m-tolylethynyl)pyrimidine::CHEMBL508497

SMILES Cc1cccc(c1)C#Cc1cncnc1

InChI Key InChIKey=WDWDORGIXVCIQC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243109   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243109(5-(m-tolylethynyl)pyrimidine | 5-(2-m-tolylethynyl...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium fluorescenceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243109(5-(m-tolylethynyl)pyrimidine | 5-(2-m-tolylethynyl...)
Affinity DataIC50: 7.5nMAssay Description:Negative allosteric modulator activity at rat mGluR5 receptor expressed in HEK293A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243109(5-(m-tolylethynyl)pyrimidine | 5-(2-m-tolylethynyl...)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243109(5-(m-tolylethynyl)pyrimidine | 5-(2-m-tolylethynyl...)
Affinity DataIC50: 7.5nMAssay Description:Positive allosteric modulation activity at mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed