BDBM50243812 CHEMBL4059667

SMILES CN([C@@H]1C[C@@H](C1)NS(=O)(=O)C1CC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=FEWYOEFWRYEMQU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50243812   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50243812(CHEMBL4059667)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50243812(CHEMBL4059667)
Affinity DataIC50: 89nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50243812(CHEMBL4059667)
Affinity DataIC50: 770nMAssay Description:Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50243812(CHEMBL4059667)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of JAK2 in CD34+ human whole blood assessed as reduction in EOP induced STAT5 phosphorylation preincubated for 45 mins followed by EOP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
LigandPNGBDBM50243812(CHEMBL4059667)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human TYK2 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed