BDBM50245256 9-hydroxy-6-(3-(4-methylpiperazin-1-yl)propyl)-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL453347

SMILES CN1CCN(CCCn2c3ccc(O)cc3c3c4C(=O)NC(=O)c4c(cc23)-c2ccccc2)CC1

InChI Key InChIKey=FNLZQIHHIXKRNH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245256   

TargetSerine/threonine-protein kinase Chk1(Human)
University of Auckland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245256BDBM50245256(9-hydroxy-6-(3-(4-methylpiperazin-1-yl)propyl)-4-p...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
University of Auckland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245256BDBM50245256(9-hydroxy-6-(3-(4-methylpiperazin-1-yl)propyl)-4-p...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50245256BDBM50245256(9-hydroxy-6-(3-(4-methylpiperazin-1-yl)propyl)-4-p...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed