BDBM50245904 CHEMBL459044::N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide

SMILES CCOc1ccccc1Oc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C(=O)Nc1c(C)cccc1C

InChI Key InChIKey=HXBMTVMACYGAGE-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50245904   

TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi:  13nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi:  20nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi:  74nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi:  78nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi:  100nMAssay Description:Inhibition of flag-tagged ACK1 autophosphorylation expressed in human 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi: >8.30E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50245904(N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(p...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed