BDBM50246461 4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imidazol-5-yl)pyrimidin-2-amine::CHEMBL452598

SMILES COc1ccc2OCC(Cc2c1)c1nc2cc(cc(F)c2[nH]1)-c1ccnc(N)n1

InChI Key InChIKey=LGNRWEUQQPIDQM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50246461   

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed