BDBM50248050 CHEMBL455655::N-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide

SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1

InChI Key InChIKey=JHTHXZUWKNWHSN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248050   

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50248050(N-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50248050(N-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-fused recombinant c-Met catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248050(N-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 26nMAssay Description:Inhibition of GST-fused recombinant VGFR2 catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50248050(N-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 140nMAssay Description:Inhibition of TPR-fused Met phosphorylation expressed in human 293T cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed