BDBM50248088 CHEMBL464211::N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(4-fluorophenyl)-2-oxoimidazolidine-1-carboxamide

SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1

InChI Key InChIKey=GTDCAFNNNVCDJN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50248088   

TargetVascular endothelial growth factor receptor 2(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-fused recombinant VGFR2 catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 27nMAssay Description:Inhibition of GST-fused recombinant c-Met catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 29nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 50nMAssay Description:Inhibition of TPR-fused Met phosphorylation expressed in human 293T cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 80nMAssay Description:Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248088(N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyr...)
Affinity DataIC50: 240nMAssay Description:Inhibition of c-Met-mediated migration in HGF-stimulated human A549 cells by wound healing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed