BDBM50248976 CHEMBL4067927

SMILES CC1(C)Oc2cc(ccc2-c2[nH]c(nc12)-c1c(F)cccc1Cl)C#Cc1cc(Cl)ccc1F

InChI Key InChIKey=OLLNGTMXDVKPPM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248976   

TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248976(CHEMBL4067927)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation using PGH2 a substrate preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248976(CHEMBL4067927)
Affinity DataIC50: 60nMAssay Description:Inhibition of COX1 in human U937 cells assessed as decrease in PGE2 release using arachidonic acid as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248976(CHEMBL4067927)
Affinity DataIC50: 839nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as decrease in IL1beta induced PGE2 release preincubated for 30 mins followed by IL-1beta addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248976(CHEMBL4067927)
Affinity DataIC50: 9.88E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 insect cells assessed as decrease in PGE2 release u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed