BDBM50249082 4-(benzofuran-2-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(5-(4-methylbenzylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one::CHEMBL471720

SMILES Cc1ccc(CSc2nnc(s2)N2C(C(C(=O)c3cc4ccccc4o3)C(=O)C2=O)c2ccccc2F)cc1

InChI Key InChIKey=GXKZEXIZVRUVLG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50249082   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50249082(4-(benzofuran-2-carbonyl)-5-(2-fluorophenyl)-3-hyd...)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50249082(4-(benzofuran-2-carbonyl)-5-(2-fluorophenyl)-3-hyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed