BDBM50249265 (R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate::CHEMBL474418

SMILES C[C@](N)(COP(O)(O)=O)c1nc(c[nH]1)-c1ccc(OCCc2ccc(cc2)-c2ccccc2)cc1

InChI Key InChIKey=YWXALJUJDPVVHS-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249265   

TargetSphingosine 1-phosphate receptor 1(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at human S1P1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataIC50: 7.70nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataIC50: 26.9nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataEC50:  54.8nMAssay Description:Agonist activity at human S1P3 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataIC50: 207nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataIC50: 210nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed