BDBM50249869 3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxamide::CHEMBL491930

SMILES O=C(Nc1cnc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21

InChI Key InChIKey=MKVJQAZEXGSAIT-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50249869   

TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]PYY from rat NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NPY Y2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human recombinant NPY Y5 receptor expressed in mouse LMtk- cells assessed as inhibition of NPY-induced Ca2+ increaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NPY Y1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249869(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human NPY Y4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed