BDBM50250135 CHEMBL4060201

SMILES ONC(=O)CCCCCCn1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=YRRVLBINSXVLFM-UHFFFAOYSA-N

Data  13 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50250135   

TargetHistone deacetylase 6(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in Baculovirus infected insect ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of C-terminal GST tagged human recombinant HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of C-terminal FLAG His tagged full length human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus infected sf21 cells using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 17nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 19nMAssay Description:Inhibition of human HDAC10 using fluorogenic peptide from p53 residues 379 to 382 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 31nMAssay Description:Inhibition of C-terminal His tagged human recombinant HDAC11 (1 to 347 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 75nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 188nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 469nMAssay Description:Inhibition of C-terminal His tagged human recombinant HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 569nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to N-terminal His tagged human recombinant JAK2 (1014 to 1132 residues) expressed in Escherichia coli after 60 to 90 mins by LC/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of C-terminal His tagged human recombinant HDAC5 (657 to 1123 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250135(CHEMBL4060201)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of N-terminal GST tagged human recombinant HDAC7 (518 to 991 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed