BDBM50250136 CHEMBL4095596

SMILES CC(CCCCCC(=O)NO)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=RTLKDFQWSQARBW-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50250136   

TargetHistone deacetylase 6(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 6nMAssay Description:Inhibition of C-terminal FLAG His tagged full length human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus infected sf21 cells using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 11nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in Baculovirus infected insect ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 31nMAssay Description:Inhibition of human HDAC10 using fluorogenic peptide from p53 residues 379 to 382 as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal GST tagged human recombinant HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 65nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 144nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 310nMAssay Description:Inhibition of C-terminal His tagged human recombinant HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 436nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of C-terminal His tagged human recombinant HDAC5 (657 to 1123 residues) expressed in Baculovirus infected insect cells in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50250136(CHEMBL4095596)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of HDAC9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed