BDBM50250862 CHEMBL4076625

SMILES OC(=O)c1ccc2nc(sc2c1)N1CCC(CC1)OCc1c(onc1-c1ccccc1C(F)(F)F)C1CC1

InChI Key InChIKey=XBAISJNMOCEHND-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50250862   

TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250862(CHEMBL4076625)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250862(CHEMBL4076625)
Affinity DataEC50:  66nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed