BDBM50250905 CHEMBL4097991::US10696655, Example 17::US11168070, Example 17

SMILES CC(=O)N1CCc2c(C1)cc(N1CCCc3cc(-c4cnn(C)c4)c(cc13)C(F)F)c(=O)n2C

InChI Key InChIKey=DEUYPPYMBKHUGL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50250905   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50250905(CHEMBL4097991 | US10696655, Example 17 | US1116807...)
Affinity DataIC50: 47nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50250905(CHEMBL4097991 | US10696655, Example 17 | US1116807...)
Affinity DataIC50: 47nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50250905(CHEMBL4097991 | US10696655, Example 17 | US1116807...)
Affinity DataIC50: 47nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50250905(CHEMBL4097991 | US10696655, Example 17 | US1116807...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed